The 2021 NFL season-opener is rapidly approaching, and the preseason is already underway. Last week, the Hall of Fame excited fans with an appetizer. This week, there is a full J. D. Martinez Jersey slate, including Friday's tilt between the and . Buffalo will travel 250 miles to Detroit for the first preseason game for each side.Kickoff from Ford Field is set for 7 p.m. ET. The latest Bills vs. Lions odds from Caesars Sportsbook list Detroit as a 1.5-point home favorite. The over-under for total points expected is set at 36.5. Before locking in any Lions vs. Bills picks or NFL predictions, .CBS Sports' Fantasy and gambling editor, White ended the 2020 season on an 80-59 run Bobby Doerr Jersey on all NFL picks, returning more than $1,400 during that span. It's no surprise, as White has cashed huge twice in the world's most prestigious football handicapping competition, the Las Vegas SuperContest.In addition, White has gone an astounding 40-22-2 on his last 64 involving the Lions, returning more than $1,500. Anyone who has followed him is way up. Now, White has set his sights on Bills vs. Lions and recently revealed his expert picks and analysis. . Now, here are several and betting trends for Lions vs. Bills:Bills vs. Lions spread: Lions -1.5Bills vs. Lions over-under: 36.5 pointsBills vs. Lions money line: Bills +100, Lions -120BUF: Bills were 12-7 against the spread in 2020DET: Lions were 7-9 against the spread in 2020Why the Bills can coverThe Bills are clearly the more talented team from an overall roster standpoint. Yes, they are on the road, but that isn't a ma sive roadblock in a preseason setting. won't start, but Buffalo could also benefit from having a backup quarterback with starting experience in.The Lions may push harder but, for as long as the Bills are using their better players, they have the advantage. There is also a chance that Detroit's Joe Kelly Jersey roster, even if deployed optimally, may not have enough to unseat Buffalo's second unit over a small sample. Pedro Martinez Jersey The Lions have a weakne s on the outside with a lack of explosion in their receiving corps, and that could benefit the Bills. Why the Lions can coverSimply put, the Lions have a lot more to play for than the Bills. Granted, this is a preseason scenario with low stakes, but Dan Campbell's regime has been predicated on a blue collar mentality. As such, it is reasonable to a sume that the Lions will be invested in this game.Furthermore, Detroit has more active evaluation to do with their core pieces, as Buffalo knows what they are and should be conservative in nature. projects to get reps for the Lions, and Detroit also stocked up on the offensive line, giving them hope of keeping their new quarterback clean. The Bills haven't been dynamic in rushing the pa ser lately, ranking near the bottom of the NFL in sacks last season, and Buffalo's second and third unit should see plenty of time on both sides of the ball.How to make Bills vs. Lions picksWhite has analyzed this matchup from all angles and while we can tell you he's leaning over Ted Williams Jersey the total, he has discovered a critical X-factor that has him jumping all over one side of the spread. . So who wins Bills vs. Lions? And which critical X-factor makes one side of the spread a ma sive value? and find out.